Colloquium: Andreas Möglich
Vrije Universiteit, WN-Q112, De Boelelaan 1081, 1081 HV Amsterdam
Colloquium: Controlling Nucleic Acids by Light
Prof. Dr. Andreas Möglich - Department of Biochemistry, Faculty of Biology, Chemistry & Earth Science, University of Bayreuth, Germany
Sensory photoreceptors underpin diverse adaptations of organismal behavior, lifestyle and physiology to incident light. In optogenetics, photoreceptors double as genetically encoded, light-gated actuators and enable the noninvasive control of cellular circuits with spatiotemporal precision. Against this backdrop, we investigate and engineer blue-light-responsive receptors of the light-oxygen-voltage (LOV) family that mediate optogenetic control of various nucleic-acid-based processes, e.g., transcription, translation and endonuclease activity. Biochemical analyses of receptor structure, function and signaling mechanism unravel the molecular bases for light-dependent allostery and inform additional protein engineering efforts.